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Results 1 to 25 of 492

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Rectal, oral and I. A. administration of etomidate to rats : significant avoidance of hepatic first-pass elimination following rectal administrationDE BOER, A. G; BREIMER, D. D.Archives internationales de pharmacodynamie et de thérapie. 1984, Vol 270, Num 2, pp 180-191, issn 0003-9780Article

Nonlinear bioavailability of metoclopramide in the rat: evidence for saturable first-pass metabolismKAPIL, R. P; AXELSON, J. E; ONGLEY, R et al.Journal of pharmaceutical sciences. 1984, Vol 73, Num 2, pp 215-218, issn 0022-3549Article

Probability of failure in Random vibrationNIELSEN, S. R. K; SORENSEN, J. D.Journal of engineering mechanics. 1988, Vol 114, Num 7, pp 1218-1230, issn 0733-9399Article

Metabolic first-pass effectsPANG, K. S.Journal of clinical pharmacology. 1986, Vol 26, Num 8, pp 580-582, issn 0091-2700Article

A new model-independent physiological approach to study hepatic drug clearance and its applicationsCHIOU, W. L.International journal of clinical pharmacology, therapy and toxicology (1980). 1984, Vol 22, Num 11, pp 577-590, issn 0174-4879Article

Self-Emulsifying Drug Delivery Systems (SEDDS): Formulation Development, Characterization, and ApplicationsSINGH, Bhupinder; BANDOPADHYAY, Shantanu; KAPIL, Rishi et al.Critical reviews in therapeutic drug carrier systems. 2009, Vol 26, Num 5, pp 427-521, issn 0743-4863, 95 p.Article

Pharmacokinetic approach to the estimation of hepatic removal of insulinBERZINS, R; TAM, Y. K; MOLNAR, G. D et al.Pancreas. 1986, Vol 1, Num 6, pp 544-549, issn 0885-3177Article

Effects of d,l-verapamil on atrioventricular conduction in relation to its stereoselective first-pass metabolismECHIZEN, H; VOGELGESANG, B; EICHELBAUM, M et al.Clinical pharmacology and therapeutics. 1985, Vol 38, Num 1, pp 71-76, issn 0009-9236Article

First pass metabolism of ethanol ― A gastrointestinal barrier against the systemic toxicity of ethanolJULKUNEN, R. J. K; DI PADOVA, C; LIEBER, C. S et al.Life sciences (1973). 1985, Vol 37, Num 6, pp 567-573, issn 0024-3205Article

Distribution of mean first-passage times in random chains due to disorderKEHR, K. W; MURTHY, K. P. N.Physical review. A, General physics. 1990, Vol 41, Num 10, pp 5728-5730, issn 0556-2791Article

Effect of allopurinol on the first-pass metabolism of 6-mercaptopurine in the ratSASAKI, H; TSURU, K; NAKAMURA, J et al.Biochemical pharmacology. 1987, Vol 36, Num 23, pp 4175-4176, issn 0006-2952Article

Glucuronidation in the rat intestinal wallKOSTER, A. S; MEEWISSE, C. P. J; FRANKHUIJZEN-SIEREVOGEL, A. C et al.Biochemical pharmacology. 1985, Vol 34, Num 3, pp 421-422, issn 0006-2952Article

Pharmacokinetics of triamterne after i.v. administration to man: determination of bioavailabilityGILFRICH, H. J; KREMER, G; MOHRKE, W et al.European journal of clinical pharmacology. 1983, Vol 25, Num 2, pp 237-241, issn 0031-6970Article

The role of metabolites in bioequivalency assessment. II: Drugs with linear pharmacokinetics and first-pass effectMEI-LING CHEN; JACKSON, A. J.Pharmaceutical research. 1995, Vol 12, Num 5, pp 700-708, issn 0724-8741Article

Theoretical considerations in the calculation of bioavailability of drugs exhibiting Michaelis-Menten elimination kineticsRUBIN, G. M; TOZER, T. N.Journal of pharmacokinetics and biopharmaceutics. 1984, Vol 12, Num 4, pp 437-450, issn 0090-466XArticle

Mean hepatic transit time in the determination of mean absorption timeCHIOU, W. L.Journal of pharmaceutical sciences. 1983, Vol 72, Num 11, pp 1365-1368, issn 0022-3549Article

Dose-independent pharmacokinetics of metformin in rats : Hepatic and gastrointestinal first-pass effectsCHOI, Young H; KIM, Sang G; LEE, Myung G et al.Journal of pharmaceutical sciences. 2006, Vol 95, Num 11, pp 2543-2552, issn 0022-3549, 10 p.Article

Hepatic and intestinal first-pass effects of oltipraz in ratsBAE, Soo K; KIM, Jin W; KIM, Young H et al.Biopharmaceutics & drug disposition. 2005, Vol 26, Num 4, pp 129-134, issn 0142-2782, 6 p.Article

Low oral bioavailability and pharmacokinetics of senkyunolide a, a major bioactive component in rhizoma chuanxiong, in the ratRU YAN; GE LIN; NGA LING KO et al.Therapeutic drug monitoring. 2007, Vol 29, Num 1, pp 49-56, issn 0163-4356, 8 p.Article

THE PHYSIOLOGICAL SIGNIFICANCE OF THE APPARENT VOLUME OF DISTRIBUTION, VDAREA OR VDBETA , IN PHARMACOKINETIC STUDIESCHIOU WL.1981; RES. COMMUN. CHEM. PATHOL. PHARMACOL.; ISSN 0034-5164; USA; DA. 1981; VOL. 33; NO 3; PP. 499-508; BIBL. 2 P.Article

GOLD-195 M: NEUE DIAGNOSTISCHE MOEGLICHKEITEN IN DER NUKLEARMEDIZIN MIT EINEM ULTRAKURZLEBENDEN RADIONUKLID = L'OR 195M: DES POSSIBILITES DIAGNOSTIQUES NOUVELLES EN MEDECINE NUCLEAIRE AVEC UN RADIOISOTOPE A VIE TRES COURTESCHNEIDER J.1983; BIOMEDIZINISCHE TECHNIK; ISSN 0013-5585; DEU; DA. 1983; VOL. 28; NO 7-8; PP. 173-176; ABS. ENG; BIBL. 16 REF.Article

FIRST-PASS, FORMATION-RATE-LIMITING METABOLISMCOLBURN WA.1983; JOURNAL OF PHARMACEUTICAL SCIENCES; ISSN 0022-3549; USA; DA. 1983; VOL. 72; NO 6; PP. 711-713; BIBL. 2 REF.Article

PRO-DRUGS AND FIRST-PASS EFFECTSJOHNSON P.1980; CHEM. IND. (LOND.); ISSN 0009-3068; GBR; DA. 1980; NO 11; PP. 443-447; BIBL. 34 REF.Article

UEBER DIE BIOVERFUEGBARKEIT ORAL VERABREICHTER MEDIKAMENTE UNTER BESONDERER BERUECKSICHTIGUNG DER LEBER ALS FREMDSTOFF-FILTER = BIODISPONIBILITE DE MEDICAMENTS ADMINISTRES PAR VOIE ORALE. IMPORTANCE DU FOIE EN TANT QUE FILTRE DE SUBSTANCES ETRANGERESRAAFLAUB J.1980; SCHWEIZ. MED. WSCHR.; CHE; DA. 1980; VOL. 110; NO 10; PP. 354-362; ABS. ENG; BIBL. 17 REF.Article

DISPOSITION, DISTRIBUTION, AND LIVER FIRST-PASS EFFECT OF PINAZEPAM IN THE RATPACIFICI GM; CUOCI L; PLACIDI GF et al.1982; DRUG METAB. DISPOS.; ISSN 0090-9556; USA; DA. 1982; VOL. 10; NO 2; PP. 180-182; BIBL. 18 REF.Article

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